Anti-HIF-2-alpha antibody [BL-95-1A2],Abcam,AB243861

What is this antibody validated in? Anti-HIF-2-alpha antibody [BL-95-1A2] (ab243861) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), ChIP in Human samples. Other related products We have a range of other formats of antibody clone [BL-95-1A2] also available for your convenience: ab243861, ab272041 REACH authorisation Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances. It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses. This product is sold under License from Bethyl Laboratories, Inc.

Host

Rabbit

Reactivity

Human

Application

ICC, IHC-P, ChIP-seq, ICC/IF, WB, IP

Platform ID

BAB455448160

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-HIF-2-alpha antibody [BL-95-1A2]
Cat. No.AB243861
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationICC, IHC-P, ChIP-seq, ICC/IF, WB, IP
ClonalityMonoclonal
Clone NumberBL-95-1A2
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human EPAS1 aa 400-450. The exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.8 - 8.6 Preservative: 0.09% Sodium azide Constituents: 98% Borate buffered saline, 0.1% BSA
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity). See full target information EPAS1

Category Paths

Request a product

Please provide the required information below so that we can quickly source your products.