Anti-HINT1 antibody [EPR5108],Abcam,AB124912

Target data Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed : 15703176, PubMed : 16835243, PubMed : 17217311, PubMed : 17337452, PubMed : 22329685, PubMed : 23614568, PubMed : 28691797, PubMed : 29787766, PubMed : 31990367). Hydrolyzes adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate) (PubMed : 15703176, PubMed : 16835243). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester (PubMed : 15703176, PubMed : 17337452, PubMed : 22329685). Hydrolyzes 3-indolepropionic acyl-adenylate, tryptamine adenosine phosphoramidate monoester and other fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed : 17217311, PubMed : 17337452, PubMed : 23614568, PubMed : 28691797, PubMed : 29787766, PubMed : 31990367). Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide (PubMed : 30772266). In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1 (PubMed : 16014379, PubMed : 22647378). Modulates p53/TP53 levels and p53/TP53-mediated apoptosis (PubMed : 16835243). Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed : 19112177). Also exhibits SUMO-specific isopeptidase activity, deconjugating SUMO1 from RGS17 (PubMed : 31088288). Deconjugates SUMO1 from RANGAP1 (By similarity). See full target information HINT1