Anti-HP1 alpha antibody [EPR5777] - Heterochromatin marker,Abcam,AB109028
What is this antibody validated in? Anti-HP1 alpha antibody [EPR5777] - Heterochromatin marker (ab109028) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human, Mouse, Rat samples. What is the molecular weight of HP1 alpha? Anti-HP1 alpha [EPR5777] - Heterochromatin marker (ab109028) specifically detects a band for HP1 alpha (UniProt: P45973) at a molecular weight of 22kDa. Trusted by the scientific community Anti-HP1 alpha [EPR5777] - Heterochromatin marker (ab109028) was first used in a scientific publication in 2011 and has been cited over 10 times in peer-reviewed journals. Reviewed by scientists Anti-HP1 alpha [EPR5777] - Heterochromatin marker (ab109028) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-HP1 alpha antibody [EPR5777] - Heterochromatin marker (ab109028) has been confirmed by Western blot testing in CBX5 Knockout HAP1 cells. Other related products We have a range of other formats of antibody clone [EPR5777] also available for your convenience: ab109028, Alexa Fluor® 488 - ab185018 , HRP - ab197721 , Alexa Fluor® 647 - ab198391 , Alexa Fluor® 594 - ab203431 , Alexa Fluor® 555 - ab203432 , PE - ab210585 , Carrier free - ab226049 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
ICC/IF, IHC-P, IP, WB, Flow Cyt (Intra)
Platform ID
BAB524626203
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression (PubMed : 40440427). In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed : 19783980). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed : 16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed : 16127177). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed : 19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed : 19783980, PubMed : 20231385). Required for the formation of the inner centromere (PubMed : 20231385). See full target information CBX5
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