Anti-HP1 alpha antibody [RAB-C133],Abcam,AB317725

Host

Human

Reactivity

Human

Application

WB, ICC/IF, Flow Cyt (Intra)

Platform ID

BAB837132450

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-HP1 alpha antibody [RAB-C133]
Cat. No.AB317725
HostHuman
IsotypeUnknown
ReactivityHuman
ApplicationWB, ICC/IF, Flow Cyt (Intra)
ClonalityMonoclonal
Clone NumberRAB-C133
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human CBX5 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Proclin 300 Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed : 19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed : 19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed : 19783980, PubMed : 20231385). Required for the formation of the inner centromere (PubMed : 20231385). See full target information CBX5

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