Anti-HPV18 E7 antibody [8E2],Abcam,AB100953
What is this antibody validated in? Anti-HPV18 E7 antibody [8E2] (ab100953) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), Immunocytochemistry/immunofluorescence (ICC/IF), ELISA in Human papillomavirus samples. What is the molecular weight of HPV18 E7? Anti-HPV18 E7 [8E2] (ab100953) specifically detects a band for HPV18 E7 (UniProt: P06788) at a molecular weight of 12kDa. Trusted by the scientific community Anti-HPV18 E7 [8E2] (ab100953) was first used in a scientific publication in 2010 and has been cited over 10 times in peer-reviewed journals.
Host
Mouse
Reactivity
Human papillomavirus
Application
WB, ELISA, IP, ICC/IF
Platform ID
BAB774951047
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta) (PubMed : 26405230). See full target information E7
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
Please provide the required information below so that we can quickly source your products.