Anti-HSD17B3 antibody,Abcam,AB126228

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

IHC-P, WB

Platform ID

BAB906110589

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-HSD17B3 antibody
Cat. No.AB126228
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ApplicationIHC-P, WB
ClonalityPolyclonal
Concentration0.66 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human HSD17B3 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed : 16216911, PubMed : 26545797, PubMed : 27927697, PubMed : 8075637). Favors the reduction of androstenedione to testosterone (PubMed : 16216911, PubMed : 26545797, PubMed : 27927697). Testosterone is the key androgen driving male development and function (PubMed : 8075637). Uses NADPH while the two other EDH17B enzymes use NADH (PubMed : 16216911, PubMed : 26545797, PubMed : 8075637). Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 (PubMed : 16216911). Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed : 16216911, PubMed : 27927697). See full target information HSD17B3

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