Anti-Hexokinase 1 antibody [EPR10134(B)] - Mitochondrial Outer Membrane Marker,Abcam,AB150423
What is this antibody validated in? Anti-Hexokinase 1 antibody [EPR10134(B)] - Mitochondrial Outer Membrane Marker (ab150423) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF), Multiplex IHC (mIHC) in Human, Mouse, Rat samples. What is the molecular weight of Hexokinase 1? Anti-Hexokinase 1 [EPR10134(B)] - Mitochondrial Outer Membrane Marker (ab150423) specifically detects a band for Hexokinase 1 (UniProt: P19367) at a molecular weight of 102kDa. Trusted by the scientific community Anti-Hexokinase 1 [EPR10134(B)] - Mitochondrial Outer Membrane Marker (ab150423) was first used in a scientific publication in 2012 and has been cited over 10 times in peer-reviewed journals. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Specificity confirmed The specificity of Anti-Hexokinase 1 antibody [EPR10134(B)] - Mitochondrial Outer Membrane Marker (ab150423) has been confirmed by Western blot testing in HK1 Knockout HEK293T cell line, ab267279 . Other related products We have a range of other formats of antibody clone [EPR10134(B)] also available for your convenience: ab150423, Alexa Fluor® 488 - ab184818 , Alexa Fluor® 647 - ab197864 , Carrier free - ab233837 , PE - ab303119 , APC - ab303120 , HRP - ab303121 , Alkaline Phosphatase - ab308989 , Alexa Fluor® 594 - ab310762 , Alexa Fluor® 555 - ab312289 , Alexa Fluor® 568 - ab312784 , ab317788 , Carrier free - ab317798 , Alexa Fluor® 750 - ab321126 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, mIHC, WB, Flow Cyt (Intra), ICC/IF
Platform ID
BAB392267237
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed : 1637300, PubMed : 25316723, PubMed : 27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed : 27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed : 27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed : 27374331). See full target information HK1
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