Anti-Histone H2A.Z antibody - ChIP Grade,Abcam,AB4174

What is this antibody validated in? Anti-Histone H2A.Z antibody - ChIP Grade (ab4174) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP), ChIP in Cow, Human, Mouse, Rat samples. What is the molecular weight of Histone H2A.Z? Anti-Histone H2A.Z - ChIP Grade (ab4174) specifically detects a band for Histone H2A.Z (UniProt: P0C0S5) at a molecular weight of 13.4kDa. Trusted by the scientific community Anti-Histone H2A.Z - ChIP Grade (ab4174) was first used in a scientific publication in 2004 and has been cited over 140 times in peer-reviewed journals. Reviewed by scientists Anti-Histone H2A.Z - ChIP Grade (ab4174) has over 25 independent reviews from customers.

Host

Rabbit

Reactivity

Cow, Human, Mouse, Rat

Application

WB, ChIP

Platform ID

BAB706372716

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Histone H2A.Z antibody - ChIP Grade
Cat. No.AB4174
HostRabbit
IsotypeIgG
ReactivityCow, Human, Mouse, Rat
ApplicationWB, ChIP
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. See full target information H2AZ1

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