Anti-Histone H2B antibody [IGX4228H],Abcam,AB213288

This product was made using synthetic libraries and phage display technology. This antibody is a recombinant antibody. Human monoclonal antibody. For recommended secondary antibodies - Rabbit monoclonal Anti-Human IgG1 H&L (Alexa Fluor® 488) - ab200622 Rabbit monoclonal Anti-Human IgG1 H&L (Alexa Fluor® 647) - ab200623 Rabbit monoclonal Anti-Human IgG1 H&L (Biotin) - ab201485 Rabbit Anti-Human IgG H&L (HRP) - ab6759

Host

Human

Reactivity

Mouse, Cow, Human

Application

ChIP, WB, PepArr

Platform ID

BAB269003903

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Histone H2B antibody [IGX4228H]
Cat. No.AB213288
HostHuman
IsotypeIgG1
ReactivityMouse, Cow, Human
ApplicationChIP, WB, PepArr
ClonalityMonoclonal
Clone NumberIGX4228H
Concentration0.474 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. See full target information H2BC12

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