Anti-Histone H3 antibody - Nuclear Marker,Abcam,AB18521

Anti-Histone H3 antibody (ab18521) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, IP, Western Blot in chinese hamster, human, mouse, rat samples. Anti-Histone H3 antibody (ab18521) has been cited over 83 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Histone H3 antibody (ab18521) has high sensitivity and specificity. Anti-Histone H3 antibody (ab18521) has 7 independent reviews from customers. Anti-Histone H3 antibody (ab18521) specifically detects Histone H3 (UniProt ID: P68431; Molecular weight: 15kDa) and is sold in 100 µg selling sizes. Histone H3 is a fundamental protein involved in maintaining chromatin structure and regulating gene expression. Utilizing this antbody for histone h3 western blot techniques can significantly enhance the detection and study of post-translational modifications on Histone H3. Research indicates that these modifications play a crucial role in epigenetics, influencing various cellular processes and disease states. Histone H3 modifications regulate gene expression in cancer and other diseases. Abnormal modifications are linked to pediatric tumors, neurodevelopmental syndromes, and disrupted cellular functions.

Host

Rabbit

Reactivity

Cow, Human, Saccharomyces cerevisiae

Application

WB, IHC-P, ICC/IF, IP

Platform ID

BAB644591121

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Histone H3 antibody - Nuclear Marker
Cat. No.AB18521
HostRabbit
IsotypeIgG
ReactivityCow, Human, Saccharomyces cerevisiae
ApplicationWB, IHC-P, ICC/IF, IP
ClonalityPolyclonal
Concentration0.19 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. See full target information H3C1

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