Anti-Histone H3 (citrulline R2 + R8 + R17) antibody,Abcam,AB5103
Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) is a rabbit polyclonal antibody and is validated for use in IP, PepArr and WB. Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) was first used in a scientific publication in 2004 and has been cited over 595 times in peer reviewed journals. It's performance in Western blot, immunofluorescence and IHC in human and mouse samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) has high sensitivity and specificity. Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) has 27 independent reviews from customers. Anti-Histone H3 (citrulline R2 + R8 + R17) antibody (ab5103) specifically detects Histone H3 Citrulline-R2, Citrulline-R8, Citrulline-R17 (UniProt ID: P68431; Molecular weight: 16kDa) and is sold in 100 µg selling sizes. Top cited antibody for this target with >800 citations. This antibody is a key tool in cancer research, particularly in understanding histone citrullination's role in tumorigenesis and is widely used in studies of gene expression, DNA repair and autoimmune diseases like rheumatoid arthritis and lupus, involving protein arginine deiminases (PADs) and NETosis. Histone hypercitrullination is reported to play a role the progression of various cancers, including multiple myeloma, acute myeloid leukaemia, lung cancer and hepatocellular carcinoma.
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IP, PepArr, WB
Platform ID
BAB269703567

Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data The protein expressed by gene H3C1 is a core component of the nucleosome, which is essential for wrapping and compacting DNA into chromatin. This process restricts DNA accessibility to cellular machineries that use DNA as a template. Consequently, histones are central to transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated through a complex set of post-translational modifications of histones, known as the histone code, and through nucleosome remodeling. This supplementary information is collated from multiple sources and compiled automatically. See full target information H3C1 citrulline R2
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
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