Anti-Histone H3 (mutated K27M) antibody [EPR18340] - ChIP Grade,Abcam,AB190631

Product Specifications Anti-Histone H3 (mutated K27M) antibody [EPR18340] - ChIP Grade (ab190631) is a rabbit recombinant monoclonal antibody and is validated for use in ChIP, Dot Blot, I-ELISA, ICC/IF, IHC-P, IP, WB in human and mouse samples. Anti-Histone H3 (mutated K27M) antibody [EPR18340] - ChIP Grade (ab190631) specifically detects Histone H3 Mutated-K27M (UniProt ID: P68431; Molecular weight: 15kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Histone H3 (mutated K27M) antibody [EPR18340] - ChIP Grade (ab190631) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Histone H3 (mutated K27M) antibody [EPR18340] - ChIP Grade (ab190631) has been cited over 12 times in peer reviewed journals and is trusted by the scientific community. Anti-Histone H3 (mutated K27M) antibody [EPR18340] - ChIP Grade (ab190631) has 4 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EPR18340 - ab240310 . Antibody clone EPR18340 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488 ( ab313663 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Human

Application

ICC/IF, Dot, ChIP, WB, I-ELISA, IP, IHC-P

Platform ID

BAB270203327

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Histone H3 (mutated K27M) antibody [EPR18340] - ChIP Grade
Cat. No.AB190631
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationICC/IF, Dot, ChIP, WB, I-ELISA, IP, IHC-P
ClonalityMonoclonal
Clone NumberEPR18340
Concentration0.807 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data The protein expressed by gene H3C1 is a core component of the nucleosome, which is essential for wrapping and compacting DNA into chromatin. This process restricts DNA accessibility to cellular machineries that use DNA as a template. Consequently, histones are central to transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated through a complex set of post-translational modifications of histones, known as the histone code, and through nucleosome remodeling. This supplementary information is collated from multiple sources and compiled automatically. See full target information H3C1 mutated K27M

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