Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade,Abcam,AB8580

Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) is a rabbit polyclonal antibody and is validated for use in ChIP, ICC/IF, IHC-P, PepArr and WB. Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) was first used in a scientific publication in 2002 and has been cited over 2135 times in peer reviewed journals. It's performance in ChIP in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) has high sensitivity and specificity. Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) has 92 independent reviews from customers. Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (ab8580) specifically detects Histone H3 Tri Methyl-K4 (UniProt ID: P68431; Molecular weight: 16kDa) and is sold in 50 µg selling sizes. Top cited antibody for this target with >2000 citations and >60 five star abreviews. Trimethylation of histone H3 (H3K4me3) is a key epigenetic mark that consistently occurs at transcription start sites, promoting higher transcription activity. H3K4me3 is considered a marker and used as a control for gene activation. It plays a crucial role in cell identity during pre-implantation development and in deriving embryonic stem cells from the inner cell mass and trophoblast stem cells from the trophectoderm. Histone H3 lysine 4 trimethylation (H3K4me3) plays a significant role in cancer by regulating gene expression and chromatin structure.

Host

Rabbit

Reactivity

Cow, Human

Application

ChIP, WB, PepArr, ICC/IF, IHC-P

Platform ID

BAB708071900

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-Histone H3 (tri methyl K4) antibody - ChIP Grade
Cat. No.AB8580
HostRabbit
IsotypeIgG
ReactivityCow, Human
ApplicationChIP, WB, PepArr, ICC/IF, IHC-P
ClonalityPolyclonal
Concentration0.9 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data The protein expressed by gene H3C1 is a core component of the nucleosome, which is essential for wrapping and compacting DNA into chromatin. This process restricts DNA accessibility to cellular machineries that use DNA as a template. Consequently, histones are central to transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated through a complex set of post-translational modifications of histones, known as the histone code, and through nucleosome remodeling. This supplementary information is collated from multiple sources and compiled automatically. See full target information H3C1 tri methyl K4

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