Anti-Histone H4 (di methyl K20) antibody,Abcam,AB9052

Host

Rabbit

Reactivity

Human, Drosophila melanogaster, Schizosaccharomyces pombe, Toxoplasma gondii, Cow, Mouse

Application

WB, IP, ICC/IF, IHC-P, ChIP

Platform ID

BAB333584154

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Histone H4 (di methyl K20) antibody
Cat. No.AB9052
HostRabbit
IsotypeIgG
ReactivityHuman, Drosophila melanogaster, Schizosaccharomyces pombe, Toxoplasma gondii, Cow, Mouse
ApplicationWB, IP, ICC/IF, IHC-P, ChIP
ClonalityPolyclonal
Concentration0.9 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level. See full target information HHF1 di methyl K20

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