Anti-Human CD25 (Camidanlumab) [Clone ADCT-301] — Fc Muted™,Leinco,C1055

Host

Human

Reactivity

Human

Platform ID

BAB571510813

Leinco

Headquarters

410 Axminister Drive St. Louis, Missouri 63026

Leinco

Contact

Tel: +1 (800) 538-1145,+1 (636) 230-9477
Fax:

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Human CD25 (Camidanlumab) [Clone ADCT-301] — Fc Muted™
Cat. No.C1055
HostHuman
ReactivityHuman
Concentration≥ 5.0 mg/ml
ImmunogenHumanized antibody derived from mouse clone targeting CD25
Purity≥95% by SDS Page ⋅ ≥95% monomer by analytical SEC
Endotoxin Level< 1.0 EU/mg as determined by the LAL method
Shipping2-8°C Wet Ice
FormulationThis biosimilar antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
StorageFunctional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.

Scientific Background

CD25 is the alpha-chain of the interleukin-2 receptor 1 , which regulates normal immune function 2 , and is involved in signal transduction, cell growth and survival 1 . CD25 is considered an attractive target for conjugated antibody chemotherapeutic development because it is overexpressed in various hematologic malignancies and is associated with poor prognosis. Antibody drug conjugates (ADC) use tumor-associated surface antigens to specifically target cancer cells with cytotoxic agents. Human therapeutic grade Camidanlumab is an ADC composed of a human CD25-directed antibody (HuMax-TAC) that is maleimide- conjugated at reduced interchain cysteines via a cathepsin-cleavable valine-alanine linker to a PBD toxin warhead (SG3199) 3 . Camidanlumab has a strong binding affinity to CD25-positive human anaplastic large cell lymphoma derived cell lines. This research grade biosimilar has the same specificity as the original therapeutic antibody but lacks the conjugated PBD toxin warhead.

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