Anti-Human CD25 (IL-2Rα) [Clone 7G7B6] — Purifiedin vivoGOLD™ Functional Grade,Leinco,C9300

Host

Mouse

Reactivity

Human

Application

ELISA,FC,in vivo,IP,WB

Platform ID

BAB196523307

Leinco

Headquarters

410 Axminister Drive St. Louis, Missouri 63026

Leinco

Contact

Tel: +1 (800) 538-1145,+1 (636) 230-9477
Fax:

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Human CD25 (IL-2Rα) [Clone 7G7B6] — Purifiedin vivoGOLD™ Functional Grade
Cat. No.C9300
HostMouse
ReactivityHuman
ApplicationELISA,FC,in vivo,IP,WB
Clone Number7G7B6
Concentration≥ 5.0 mg/ml
ImmunogenRecombinant human peripheral blood mononuclear cells (PBMCs)
Purity≥95% monomer by analytical SEC ⋅ >95% by SDS Page
Endotoxin Level< 1.0 EU/mg as determined by the LAL method
ShippingNext Day 2-8°C
FormulationThis monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
StorageFunctional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.

Scientific Background

CD25 (IL-2Rα) is the 55 kDa subunit of the interleukin 2 receptor alpha chain which has been shown to play roles in lymphocyte differentiation, activation, and proliferation. IL-2Rα is a transmembrane glycoprotein comprised of a heavily glycosylated extracellular domain, a transmembrane region and a short cytoplasmic tail. IL-2Rα heterodimerizes with IL-2Rβ (CD122) and IL-2Rγ (CD132) and forms the IL-2 receptor complex. IL-2Rα by itself binds IL-2 with relatively low affinity, while the IL-2 receptor complex binds IL-2 with high affinity. IL-2Rα mutations cause severe immunodeficiency.

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