Anti-Human CD62L [Clone DREG56] — Purifiedin vivoGOLD™ Functional Grade,Leinco,C2270

Host

Mouse

Reactivity

Human

Application

FC,IF,in vivo,WB

Platform ID

BAB447347911

Leinco

Headquarters

410 Axminister Drive St. Louis, Missouri 63026

Leinco

Contact

Tel: +1 (800) 538-1145,+1 (636) 230-9477
Fax:

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Human CD62L [Clone DREG56] — Purifiedin vivoGOLD™ Functional Grade
Cat. No.C2270
HostMouse
ReactivityHuman
ApplicationFC,IF,in vivo,WB
Clone NumberDREG56
Concentration≥ 5.0 mg/ml
ImmunogenConcentrated supernatant from PMA-activated human peripheral blood leukocytes
Purity≥95% monomer by analytical SEC ⋅ >95% by SDS Page
Endotoxin Level< 1.0 EU/mg as determined by the LAL method
ShippingNext Day 2-8°C
FormulationThis monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
StorageFunctional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.

Scientific Background

CD62L antibody, clone DREG56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes 1 . Ligands for CD62L include CD34, GlyCAM-1, and MAdCAM-1, which require sialyation, fucosylation, and carbohydrate sulfation for recognition 2,3 . Ligand binding mediates tethering and rolling of leukocytes, facilitating entry into secondary lymphoid organs, including lymph nodes and Peyer’s patches, via high endothelial venules (HEVs) 1 . CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation 4 .

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