Anti-Human CD64 (FCGR1) [Clone 10.1] — Purifiedin vivoPLATINUM™ Functional Grade,Leinco,I-2015

FCGR1 antibody, 10.1, recognizes high-affinity immunoglobulin gamma Fc receptor I (FCGR1), also known as CD64. FCGR1 is a 72 kDa type I transmembrane glycoprotein expressed on monocytes, macrophages, and dendritic cells (DCs). FCGR1 can also be induced on neutrophils with IFNγ and G-CSF 1 . FCGR1 binds with high affinity to monomeric IgG1 and IgG3, and to a lesser extent, IgG4 2 , resulting in phosphorylation of the intracellular FCGR1 ITAM motif and subsequent recruitment of Syk. FCGR1 contributes to inflammation via several mechanisms, including promoting antibody-dependent cell-mediated cytotoxicity (ADCC), clearance of immune complexes, cytokine production, and antigen presentation 1,3 . CD64-based targeted therapies eliminate M1 pro-inflammatory macrophages and show clinical potential for the treatment of macrophage-mediated chronic inflammatory diseases, such as chronic cutaneous inflammation and rheumatoid arthritis 4 . In addition, CD64 promotes antitumor responses and mediates cytotoxic killing of tumor cells by macrophages 5 .