Anti-Human GC1q R (C1QBP) [Clone 60.11] – Purifiedin vivoGOLD™ Functional Grade,Leinco,G234

The globular C1q Receptor (gC1qR), encoded by the C1QBP gene, is a highly acidic, doughnut-shaped homotrimer that serves as a central hub for complement activation and inflammatory signaling. While predominantly mitochondrial (where it regulates oxidative phosphorylation), surface-translocated gC1qR acts as a receptor for the globular heads of C1q, the recognition molecule of the classical complement pathway 1 . Beyond complement, gC1qR interacts with the kinin-kallikrein system (Factor XII, High-Molecular-Weight Kininogen) to drive the production of bradykinin, a potent vasoactive peptide that promotes vascular permeability and inflammation 4 . In the context of cancer, surface gC1qR facilitates tumor cell proliferation and migration by activating the PI3K/Akt and ERK signaling pathways. It also suppresses the oxidative burst in phagocytes, thereby aiding tumor immune evasion 3,5 . Clone 60.11 is a functional blocking antibody widely utilized to dissect these pathogenic axes. By binding specifically to the C1q-binding site, 60.11 prevents the interaction between gC1qR and C1q, effectively neutralizing downstream inflammatory signals 1 . In preclinical models of triple-negative breast cancer (TNBC), treatment with 60.11 significantly inhibited tumor growth and reduced angiogenesis (CD31+ vessel density) by blocking gC1qR-dependent mitogenic signaling 5 . Additionally, 60.11 has been shown to reduce tissue colonization by Staphylococcus aureus in models of infective endocarditis, as the bacteria exploit host gC1qR to adhere to endothelial cells 6 .