Anti-Human respiratory syncytial virus phosphoprotein VP32 antibody [3.5-18],Abcam,AB322893

What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies . Want a custom formulation? This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact [email protected]

Host

Mouse

Reactivity

Human respiratory syncytial virus A (strain A2), Human respiratory syncytial virus B (strain B1)

Application

I-ELISA, ICC/IF, WB

Platform ID

BAB220815780

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Human respiratory syncytial virus phosphoprotein VP32 antibody [3.5-18]
Cat. No.AB322893
HostMouse
IsotypeIgG1
ReactivityHuman respiratory syncytial virus A (strain A2), Human respiratory syncytial virus B (strain B1)
ApplicationI-ELISA, ICC/IF, WB
ClonalityMonoclonal
Clone Number3.5-18
Concentration0.978 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays critical roles in regulating RNA replication and transcription through its interactions with multiple proteins (PubMed : 25568210, PubMed : 26474524). Tethers the RNA-directed RNA polymerase L to the nucleoprotein-RNA complex (PubMed : 26474524). Recruits the M2-1 protein, a processivity factor that is required for efficient transcription of viral RNA (PubMed : 26474524). Acts as a chaperone for neo-synthesized nucleoprotein by forming an N-P complex that preserves N in a monomeric and RNA-free state and prevents the association of nascent N with host cell RNAs (PubMed : 25568210). Recruits the host phosphatase PP1 to inclusion bodies to regulate viral transcription (PubMed : 29489893). Together with the nucleoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (By similarity). See full target information P Additional targets P

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