Anti-ICOS antibody [SP98],Abcam,AB105227
Product Specifications Anti-ICOS antibody [SP98] (ab105227) is a rabbit recombinant monoclonal antibody and is validated for use in IHC-Fr, IHC-P in human samples. Anti-ICOS antibody [SP98] (ab105227) specifically detects ICOS (UniProt ID: Q9Y6W8; Molecular weight: 20kDa) and is sold in 100 µL, 500 µL and 1 mL selling sizes. Quality and Validation Anti-ICOS antibody [SP98] (ab105227) is a clone from the portfolio of Spring Bioscience (Roche) SP clones which have been optimised for immunohistochemistry (IHC). Abcam's high quality manufacturing and validation processes ensure Anti-ICOS antibody [SP98] (ab105227) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-ICOS antibody [SP98] (ab105227) has been cited over 14 times in peer reviewed journals and is trusted by the scientific community. Related Products Conjugation-ready, carrier free format available for antibody clone SP98 - ab236226 . Antibody clone SP98 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 594, Alexa Fluor® 568, Alexa Fluor® 555, Alexa Fluor® 750 ( ab311010 , ab311138 , ab311775 , ab313056 , ab313256 , ab320884 ). What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
IHC-P, IHC-Fr
Platform ID
BAB784346535
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response (PubMed : 9930702). Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells (PubMed : 33033255). Acts also as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (PubMed : 27135603). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (By similarity). In addition, activates PI3K signaling pathways independently of calcium flux (PubMed : 30523347). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). See full target information ICOS
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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