Anti-IKB alpha antibody,Abcam,AB7217
Host
Rabbit
Reactivity
Mouse
Application
WB
Platform ID
BAB036970275
Abcam
Contact
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Product Specifications
Scientific Background
Specifications
NameAnti-IKB alpha antibody
Cat. No.AB7217
HostRabbit
IsotypeIgG
ReactivityMouse
ApplicationWB
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Full Length Protein corresponding to Mouse Nfkbia.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 6.5 Preservative: 0.1% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed : 10097128, PubMed : 9990853). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed : 10097128, PubMed : 7878466, PubMed : 9990853). See full target information Nfkbia
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
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