Anti-IKB alpha antibody [E130],Abcam,AB32518
Product Specifications Anti-IKB alpha antibody [E130] (ab32518) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human, mouse, rat samples. Anti-IKB alpha antibody [E130] (ab32518) specifically detects IKB alpha (UniProt ID: P25963; Molecular weight: 36kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-IKB alpha antibody [E130] (ab32518) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-IKB alpha antibody [E130] (ab32518) has been confirmed by testing in knockout samples. Anti-IKB alpha antibody [E130] (ab32518) has been cited over 440 times in peer reviewed journals and is trusted by the scientific community. Anti-IKB alpha antibody [E130] (ab32518) has 31 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone E130 - ab215972 . Antibody clone E130 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, HRP, Alexa Fluor® 647, Alexa Fluor® 594, Alexa Fluor® 555, APC, PE ( ab202644 , ab202646 , ab202647 , ab206346 , ab206578 , ab224948 , ab224949 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, WB, Flow Cyt (Intra), IP, ICC/IF
Platform ID
BAB661982769

Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed : 1493333, PubMed : 36651806, PubMed : 7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed : 7479976, PubMed : 7628694, PubMed : 7796813, PubMed : 7878466). See full target information NFKBIA
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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