Anti-IL-18 antibody,Abcam,AB191860
What is this antibody validated in? Anti-IL-18 antibody (ab191860) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Mouse, Rat samples. What is the molecular weight of IL-18? Anti-IL-18 (ab191860) specifically detects a band for IL-18 (UniProt: P97636) at a molecular weight of 22kDa. Trusted by the scientific community Anti-IL-18 (ab191860) was first used in a scientific publication in 2014 and has been cited over 50 times in peer-reviewed journals.
Host
Rabbit
Reactivity
Mouse, Rat
Application
IHC-P, ELISA, WB
Platform ID
BAB539019291
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed : 26638072, PubMed : 26638073). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (By similarity). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (By similarity). Involved in transduction of inflammation downstream of pyroptosis : its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed : 30392956). See full target information Il18
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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