Anti-IL3RA/CD123 antibody [IL3RA/1531],Abcam,AB268075

Host

Mouse

Reactivity

Human

Application

IHC-P, Protein Array

Platform ID

BAB604599062

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-IL3RA/CD123 antibody [IL3RA/1531]
Cat. No.AB268075
HostMouse
IsotypeIgG2b
ReactivityHuman
ApplicationIHC-P, Protein Array
ClonalityMonoclonal
Clone NumberIL3RA/1531
Concentration0.2 - 1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human IL3RA aa 1-200. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A/G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed : 10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). See full target information IL3RA

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