Anti-INO80 antibody,Abcam,AB245619

Host

Rabbit

Reactivity

Human

Application

IP

Platform ID

BAB293492143

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-INO80 antibody
Cat. No.AB245619
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIP
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human INO80 aa 1400-1450. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair (PubMed : 16230350, PubMed : 16298340, PubMed : 17721549, PubMed : 20237820, PubMed : 20855601). Binds DNA (PubMed : 16298340, PubMed : 21303910). As part of the INO80 complex, remodels chromatin by shifting nucleosomes (PubMed : 16230350, PubMed : 21303910). Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator (PubMed : 17721549). Involved in UV-damage excision DNA repair (PubMed : 20855601). The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation (PubMed : 20687897). Involved in DNA replication (PubMed : 20237820). Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle (PubMed : 20237820). See full target information INO80

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