Anti-IQGAP1 antibody,Abcam,AB86064

Host

Rabbit

Reactivity

Human

Application

IHC-P, IP, WB

Platform ID

BAB796440727

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-IQGAP1 antibody
Cat. No.AB86064
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, IP, WB
ClonalityPolyclonal
Concentration0.2 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human IQGAP1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Recruited to the cell cortex by interaction with ILK which allows it to cooperate with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Binds to activated CDC42 but does not stimulate its GTPase activity. Associates with calmodulin. May promote neurite outgrowth (PubMed : 15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed : 20883816). See full target information IQGAP1

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