Anti-IRF8 antibody,Abcam,AB240752

Target data Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed : 12393690, PubMed : 2111015). Can both act as a transcriptional activator or repressor (PubMed : 2111015). Plays a negative regulatory role in cells of the immune system (PubMed : 2111015). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (PubMed : 12393690, PubMed : 22992524). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (PubMed : 12393690, PubMed : 12461077, PubMed : 12538667, PubMed : 23382217). Positively regulates macroautophagy in dendritic cells (By similarity). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (PubMed : 32741026). See full target information Irf8