Anti-IST1 antibody,Abcam,AB244502

Host

Rabbit

Reactivity

Human

Application

WB, IHC-P, ICC

Platform ID

BAB985483736

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-IST1 antibody
Cat. No.AB244502
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, IHC-P, ICC
ClonalityPolyclonal
Concentration0.08 - 0.1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human IST1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed : 19129479, PubMed : 26040712, PubMed : 28242692). Is required for efficient abscission during cytokinesis (PubMed : 19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed : 19129479, PubMed : 19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex : IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed : 26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed : 28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed : 23897888). See full target information IST1

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