Anti-ITM2B antibody [OTI1C11],Abcam,AB119044

Dilute in PBS (pH7.3) before use. The clone number has been updated from 1C11 to OTI1C11, both clone numbers name the same clone. This product was changed from ascites to tissue culture supernatant on 5 th September 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.

Host

Mouse

Reactivity

Human

Application

WB, IHC-P, Flow Cyt (Intra)

Platform ID

BAB860821074

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-ITM2B antibody [OTI1C11]
Cat. No.AB119044
HostMouse
IsotypeIgG2a
ReactivityHuman
ApplicationWB, IHC-P, Flow Cyt (Intra)
ClonalityMonoclonal
Clone NumberOTI1C11
ImmunogenRecombinant Full Length Protein corresponding to Human ITM2B.
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.. Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.. Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers. See full target information ITM2B

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