Anti-IZUMO1 antibody,Abcam,AB211623

Host

Rabbit

Reactivity

Mouse, Human

Application

ICC/IF, WB, IHC-P

Platform ID

BAB423452261

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-IZUMO1 antibody
Cat. No.AB211623
HostRabbit
IsotypeIgG
ReactivityMouse, Human
ApplicationICC/IF, WB, IHC-P
ClonalityPolyclonal
ImmunogenThis product was produced with the following immunogens:
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 6 - 8.5 Preservative: 0.1% Sodium azide
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1 : IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization (PubMed : 36070373). FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion (PubMed : 36070373). See full target information IZUMO1

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