Anti-Iba1 antibody [EPR16588] - Microglia marker,Abcam,AB178846
Anti-Iba1 antibody [EPR16588] (ab178846) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P and WB. Anti-Iba1 antibody [EPR16588] (ab178846) was first used in a scientific publication in 2016 and has been cited over 439 times in peer reviewed journals. It's performance in IHC, Western Blot and Immunofluorescence in mouse and rat samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Iba1 antibody [EPR16588] (ab178846) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Iba1 antibody [EPR16588] (ab178846) has 44 independent reviews from customers. Anti-Iba1 antibody [EPR16588] (ab178846) specifically detects Iba1 (UniProt ID: O70200; Molecular weight: 17kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR16588 - ab220815 . Antibody clone EPR16588 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, APC, Alexa Fluor ® 750 ( ab225260 , ab225261 , ab320071 , ab321218 ). NEW: Explore our alternative host species for clone [EPR16588] : goat, chicken, rat. Iba1 (AIF1) is a marker for microglia, the brain's primary immune cells and is frequently used in Alzheimer's disease (AD) research. In AD brains, altered Iba1 expression indicates microglial activation and neuroinflammation. Researchers use Iba1 to assess microglial response and motility in AD models, making it essential for understanding the role of inflammation and immune response in Alzheimer's pathology. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
IHC-P, IHC-Fr, ICC/IF, WB, Flow Cyt (Intra)
Platform ID
BAB471240576

Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
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Product Specifications
Scientific Background
Specifications
NameAnti-Iba1 antibody [EPR16588] - Microglia marker
Cat. No.AB178846
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationIHC-P, IHC-Fr, ICC/IF, WB, Flow Cyt (Intra)
ClonalityMonoclonal
Clone NumberEPR16588
Concentration1.152 - 1.178 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only
Scientific Background
Target data Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. See full target information AIF1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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