Anti-Integrin alpha 2 antibody [HAS-3],Abcam,AB10800

The antibody co-precipitates alpha 2 beta 1 integrin from keratinocytes and inhibits HGF induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen.

Host

Mouse

Reactivity

Human

Application

IHC-P, ICC/IF, Flow Cyt, IHC-Fr, IP

Platform ID

BAB356773018

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Integrin alpha 2 antibody [HAS-3]
Cat. No.AB10800
HostMouse
IsotypeIgG2a
ReactivityHuman
ApplicationIHC-P, ICC/IF, Flow Cyt, IHC-Fr, IP
ClonalityMonoclonal
Clone NumberHAS-3
Concentration1 mg/mL Batch dependent concentration
ImmunogenCell preparation containing ITGA2 protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.02% Sodium azide Constituents: PBS
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.. (Microbial infection) Integrin ITGA2 : ITGB1 acts as a receptor for Human rotavirus A.. (Microbial infection) Integrin ITGA2 : ITGB1 acts as a receptor for Human echoviruses 1 and 8. See full target information ITGA2

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