Anti-Integrin alpha 5 antibody [EPR7854],Abcam,AB150361
Product Specifications Anti-Integrin alpha 5 antibody [EPR7854] (ab150361) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human, mouse, rat samples. Anti-Integrin alpha 5 antibody [EPR7854] (ab150361) specifically detects Integrin alpha 5 (UniProt ID: P08648; Molecular weight: 110kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Integrin alpha 5 antibody [EPR7854] (ab150361) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-Integrin alpha 5 antibody [EPR7854] (ab150361) has been confirmed by testing in knockout samples. Anti-Integrin alpha 5 antibody [EPR7854] (ab150361) has been cited over 82 times in peer reviewed journals and is trusted by the scientific community. Anti-Integrin alpha 5 antibody [EPR7854] (ab150361) has 12 independent reviews from customers. Related Products Conjugation-ready, carrier free format available for antibody clone EPR7854 - ab239400 . Antibody clone EPR7854 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 594, APC ( ab207269 , ab221283 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Rat, Human
Application
WB, IP, IHC-P, ICC/IF, Flow Cyt (Intra)
Platform ID
BAB294491663
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Integrin alpha-5/beta-1 (ITGA5 : ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5 : ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed : 18635536, PubMed : 25398877). ITGA5 : ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed : 12807887, PubMed : 17158881). ITGA5 : ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed : 33962943). ITGA5 : ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed : 29030430). ITGA5 : ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed : 31331973).. (Microbial infection) Integrin ITGA5 : ITGB1 acts as a receptor for Human metapneumovirus.. (Microbial infection) Integrin ITGA2 : ITGB1 acts as a receptor for Human parvovirus B19.. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. See full target information ITGA5
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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