Anti-Integrin alpha 9+beta 1 antibody [Y9A2],Abcam,AB27947

This clone (Y9A2) inhibits adhesion of alpha9 expressing cells to N terminal osteopontin.

Host

Mouse

Reactivity

Guinea pig, Human, Rat

Application

Flow Cyt, IP, ICC/IF

Platform ID

BAB294591615

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Integrin alpha 9+beta 1 antibody [Y9A2]
Cat. No.AB27947
HostMouse
IsotypeIgG1
ReactivityGuinea pig, Human, Rat
ApplicationFlow Cyt, IP, ICC/IF
ClonalityMonoclonal
Clone NumberY9A2
Concentration1 mg/mL Batch dependent concentration
ImmunogenCell preparation containing ITGA9 protein. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein G
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.09% Sodium azide
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Integrin alpha-9/beta-1 (ITGA9 : ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. ITGA9 : ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrin ITGA9 : ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed : 35802072). See full target information ITGA9 Additional targets ITGB1

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