Anti-Integrin alpha V antibody [RMV-7],Abcam,AB63490

Target data The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF (PubMed : 10025398, PubMed : 9827803). They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (PubMed : 9827803). ITGAV : ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGAV : ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV : ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (By similarity). ITGAV : ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (By similarity). ITGAV : ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGAV : ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). ITGAV : ITGB3 binds to IL1B and this binding is essential for IL1B signaling (By similarity). ITGAV : ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGAV : ITGB3 and ITGAV : ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV : ITGB6 or ITGAV : ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed : 10025398, PubMed : 25127859). ITGAV : ITGB3 acts as a receptor for CD40LG (By similarity). ITGAV : ITGB3 binds to the Lilrb4a/Gp49b receptor and enhances the Lilrb4a-mediated inhibition of mast cell activation (PubMed : 11323698). ITGAV : ITGB3 also suppresses marginal zone B cell antibody production through its interaction with Lilrb4a (PubMed : 24935931). ITGAV : ITGB3 acts as a receptor for IBSP and promotes cell adhesion and migration to IBSP (By similarity). See full target information Itgav