Anti-Integrin beta 4 antibody [M126],Abcam,AB29042

Host

Mouse

Reactivity

Human

Application

Flow Cyt (Intra), WB

Platform ID

BAB420053893

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Integrin beta 4 antibody [M126]
Cat. No.AB29042
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationFlow Cyt (Intra), WB
ClonalityMonoclonal
Clone NumberM126
ImmunogenRecombinant Fragment Protein within Human ITGB4. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6 : ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed : 20682778). ITGA6 : ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed : 22351760). ITGA6 : ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed : 28873464). See full target information ITGB4

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