Anti-Islet 1 antibody [EP4182] - Neural Stem Cell Marker,Abcam,AB109517
Insulin gene enhancer protein ISL-1 is a protein encoded by the ISL1 gene. Among other roles, ISL-1 plays a part in the embryogenesis of pancreatic islets of Langerhans and some models, deficiency have shown failure of neural tube motor neurons to differentiate. Rat: We have preliminary testing data to indicate this antibody may not react with these species. Please contact us for more information. Product Specifications Anti-Islet 1 antibody [EP4182] - Neural Stem Cell Marker (ab109517) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IP, WB in chicken, human, mouse samples. Anti-Islet 1 antibody [EP4182] - Neural Stem Cell Marker (ab109517) specifically detects Islet 1 (UniProt ID: P61371; Molecular weight: 39kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-Islet 1 antibody [EP4182] - Neural Stem Cell Marker (ab109517) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Islet 1 antibody [EP4182] - Neural Stem Cell Marker (ab109517) has been cited over 59 times in peer reviewed journals and is trusted by the scientific community. Anti-Islet 1 antibody [EP4182] - Neural Stem Cell Marker (ab109517) has 6 independent reviews from customers. Related Products Antibody clone EP4182 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 594, Alexa Fluor® 555, Alexa Fluor® 568, Alexa Fluor® 488, Alexa Fluor® 647, APC, PE ( ab203404 , ab203405 , ab203406 , ab275990 , ab277925 , ab310815 , ab310894 ). Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse, Chicken, Human
Application
WB, Flow Cyt (Intra), IP, ICC/IF
Platform ID
BAB985383784
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1 (By similarity). Binds to insulin gene enhancer sequences (By similarity). Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity). See full target information ISL1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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