Anti-Junctional Adhesion Molecule 1/JAM-A antibody [RM275] - N-terminal,Abcam,AB238313

Host

Rabbit

Reactivity

Human

Application

WB, IHC-P

Platform ID

BAB736858076

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-Junctional Adhesion Molecule 1/JAM-A antibody [RM275] - N-terminal
Cat. No.AB238313
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationWB, IHC-P
ClonalityMonoclonal
Clone NumberRM275
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human F11R. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationPreservative: 0.09% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed : 11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed : 11812992). Involved in platelet activation (PubMed : 10753840).. (Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.. (Microbial infection) Acts as a receptor for Human Rotavirus strain Wa. See full target information F11R

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