Anti-KANK2 antibody,Abcam,AB99351

Target data Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed : 17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed : 22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed : 22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed : 24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed : 17996375, PubMed : 25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed : 25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity). See full target information KANK2