Anti-KCNQ2 antibody,Abcam,AB22897

Target data Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed : 24277843, PubMed : 28793216, PubMed : 9836639). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed : 10781098, PubMed : 14534157, PubMed : 32884139, PubMed : 37857637, PubMed : 9836639). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed : 14534157, PubMed : 28793216, PubMed : 9836639). KCNQ2-KCNQ3 M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed : 28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed : 28793216). Suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed : 10684873, PubMed : 10713961). See full target information KCNQ2