Anti-KDM5B / PLU1 / Jarid1B antibody [CL1129],Abcam,AB244220

Host

Mouse

Reactivity

Human

Application

IHC-P, WB, ICC/IF

Platform ID

BAB426550773

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-KDM5B / PLU1 / Jarid1B antibody [CL1129]
Cat. No.AB244220
HostMouse
IsotypeIgG1
ReactivityHuman
ApplicationIHC-P, WB, ICC/IF
ClonalityMonoclonal
Clone NumberCL1129
Concentration1 mg/mL Batch dependent concentration
ImmunogenRecombinant Fragment Protein within Human KDM5B aa 1400-1500. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed : 24952722, PubMed : 27214403, PubMed : 28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed : 24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). See full target information KDM5B

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