Anti-KDM6B / JMJD3 antibody,Abcam,AB169197

Target data Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed : 17713478, PubMed : 17825402, PubMed : 17851529, PubMed : 18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed : 17713478, PubMed : 17825402, PubMed : 17851529, PubMed : 18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed : 17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed : 17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). See full target information KDM6B