Anti-Kv4.3/KCND3 antibody - C-terminal,Abcam,AB228944

Target data Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed : 10200233, PubMed : 17187064, PubMed : 21349352, PubMed : 22457051, PubMed : 23280837, PubMed : 23280838, PubMed : 34997220, PubMed : 9843794). In cardiomyocytes, may generate the transient outward potassium current I(To) (By similarity). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation (PubMed : 10200233, PubMed : 17187064, PubMed : 21349352, PubMed : 22457051, PubMed : 23280837, PubMed : 23280838, PubMed : 34997220, PubMed : 9843794). Channel properties are modulated by interactions with regulatory subunits (PubMed : 17187064, PubMed : 34997220). Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation (PubMed : 17187064, PubMed : 34997220). Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (PubMed : 34997220). See full target information KCND3