Anti-L3MBTL3 antibody,Abcam,AB99928

Host

Rabbit

Reactivity

Human

Application

IHC-P, IP

Platform ID

BAB242505364

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-L3MBTL3 antibody
Cat. No.AB99928
HostRabbit
IsotypeIgG
ReactivityHuman
ApplicationIHC-P, IP
ClonalityPolyclonal
Concentration1 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Human L3MBTL3 aa 550-600. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: Tris citrate/phosphate
Storage+4°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed : 29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed : 29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed : 29691401, PubMed : 30442713). Required for normal maturation of myeloid progenitor cells (By similarity). See full target information L3MBTL3

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