Anti-LAMP1 antibody [EPR21026] - Lysosome Marker,Abcam,AB208943
Anti-LAMP1 antibody [EPR21026] (ab208943) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-Fr, IHC-P, IP, WB in mouse samples. Anti-LAMP1 antibody [EPR21026] (ab208943) has been cited over 31 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-LAMP1 antibody [EPR21026] (ab208943) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-LAMP1 antibody [EPR21026] (ab208943) specifically detects LAMP1 (UniProt ID: P11438; Molecular weight: 42kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR21026 - ab225762 . Antibody clone EPR21026 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 647, Alexa Fluor® 555, Alexa Fluor® 594, Alexa Fluor® 568, PE (ab23737, ab355, ab32684, ab3282 , ab314256 ). Lysosomal-associated membrane protein 1 (LAMP1) is an essential lysosomal membrane protein that plays a crucial role in cellular processes such as waste degradation and autophagy regulation. It is a significant focus of research in neuroscience and cell biology due to its importance in maintaining cellular health. Changes in LAMP1 expression are associated with various diseases, including cancer, neurodegenerative disorders like Alzheimer's disease (AD), and lysosomal storage diseases. Studying LAMP1 provides valuable insights into the mechanisms of these diseases and the cellular dysfunctions involved, highlighting its critical role in understanding disease pathology. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Mouse
Application
IP, ICC/IF, WB, IHC-Fr, Flow Cyt (Intra), IHC-P
Platform ID
BAB806535879
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed : 15121881). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Also plays an important role in NK-cells cytotoxicity (PubMed : 23847195). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (By similarity). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed : 23847195). Presents carbohydrate ligands to selectins (By similarity). Also implicated in tumor cell metastasis (PubMed : 2676155). See full target information Lamp1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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