Anti-LAMP1 antibody - Lysosome Marker,Abcam,AB24170
Anti-LAMP1 antibody - Lysosome Marker (ab24170) is a rabbit polyclonal antibody and is validated for use in IHC-P, WB. Anti-LAMP1 antibody - Lysosome Marker (ab24170) has been cited over 760 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-LAMP1 antibody - Lysosome Marker (ab24170) has high sensitivity and specificity. Anti-LAMP1 antibody - Lysosome Marker (ab24170) has 98 independent reviews from customers. Anti-LAMP1 antibody - Lysosome Membrane Marker (ab24170) specifically detects LAMP1 (UniProt ID: P11279; Molecular weight: 42kDa) and is sold in 100 µg selling sizes. LAMP1 (Lysosomal Associated Membrane Protein 1) is a protein that plays a crucial role in the lysosomal membrane's stability and function. It is widely used as a lysosome membrane marker in various cell types. LAMP1 is involved in processes such as autophagy and cellular homeostasis. Dysregulation of LAMP1 has been linked to several diseases, including cancer, where it may contribute to tumor cell metastasis, and neurodegenerative disorders like Parkinson's disease.
Host
Rabbit
Reactivity
Human
Application
WB, IHC-P
Platform ID
BAB244104596
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed : 37390818). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (PubMed : 37390818). Also plays an important role in NK-cells cytotoxicity (PubMed : 2022921, PubMed : 23632890). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed : 23632890). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed : 23847195). Presents carbohydrate ligands to selectins (PubMed : 7685349).. (Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed : 24970085, PubMed : 25972533, PubMed : 27605678, PubMed : 28448640). Also promotes fusion of the virus with host membrane in less acidic endosomes (PubMed : 29295909).. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. See full target information LAMP1
Category Paths
- Products>Primary Antibodies>Polyclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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