Anti-LARP1 antibody [EPR28797-92],Abcam,AB317575
Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .
Host
Rabbit
Reactivity
Human
Application
Dot, WB
Platform ID
BAB306985663
Abcam
Contact
Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215
Email:
Specifications
Scientific Background
Target data RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability (PubMed : 20430826, PubMed : 23711370, PubMed : 24532714, PubMed : 25940091, PubMed : 28650797, PubMed : 28673543, PubMed : 29244122). Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery (PubMed : 23711370, PubMed : 25940091, PubMed : 26206669, PubMed : 28379136, PubMed : 28650797, PubMed : 29244122). The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1 (PubMed : 25940091, PubMed : 28379136, PubMed : 28650797, PubMed : 29244122). When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA (PubMed : 25940091, PubMed : 28650797). Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif (PubMed : 28379136). Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes (PubMed : 20430826, PubMed : 24532714, PubMed : 25940091, PubMed : 28673543). Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis (PubMed : 23711370, PubMed : 28650797). Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation (PubMed : 20430826, PubMed : 24532714). Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis (PubMed : 20430826, PubMed : 23711370, PubMed : 25940091, PubMed : 28673543).. (Microbial infection) Positively regulates the replication of dengue virus (DENV). See full target information LARP1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
- Products>Trial Size Antibodies
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