Anti-LDL Receptor antibody,Abcam,AB30532

Product Specifications Anti-LDL Receptor antibody (ab30532) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human, mouse, rat samples. Anti-LDL Receptor antibody (ab30532) specifically detects Low-density lipoprotein receptor (UniProt ID: P01130; Molecular weight: 93kDa) and is sold in 50 µg selling sizes. Quality and Validation Abcam's high quality validation processes ensure Anti-LDL Receptor antibody (ab30532) has high sensitivity and specificity. Anti-LDL Receptor antibody (ab30532) has been cited over 88 times in peer reviewed journals and is trusted by the scientific community. Anti-LDL Receptor antibody (ab30532) has 12 independent reviews from customers.

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

ICC/IF, WB, IHC-P

Platform ID

BAB307885231

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Abcam

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameAnti-LDL Receptor antibody
Cat. No.AB30532
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationICC/IF, WB, IHC-P
ClonalityPolyclonal
Concentration0.2 mg/mL Batch dependent concentration
ImmunogenSynthetic Peptide within Mouse Low-density lipoprotein receptor aa 450-550. The exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Immunogen
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.4 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 40% Glycerol (glycerin, glycerine), 0.1% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization (PubMed : 30443021).. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins.. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus.. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.. (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV).. (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus. See full target information Low-density lipoprotein receptor

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