Anti-LGR5 antibody [EPR3065Y],Abcam,AB75850

What is this antibody validated in? Anti-LGR5 antibody [EPR3065Y] (ab75850) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB) in Human, Mouse, Rat samples. What is the molecular weight of LGR5? Anti-LGR5 [EPR3065Y] (ab75850) specifically detects a band for LGR5 (UniProt: O75473) at a molecular weight of 100kDa. Trusted by the scientific community Anti-LGR5 [EPR3065Y] (ab75850) was first used in a scientific publication in 2009 and has been cited over 50 times in peer-reviewed journals. Reviewed by scientists Anti-LGR5 [EPR3065Y] (ab75850) has over 5 independent reviews from customers. Trial sizes available! Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl. Discover our selection of trial-size antibodies. Other related products We have a range of other formats of antibody clone [EPR3065Y] also available for your convenience: ab75850, Carrier free - ab199335 Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents . What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies .

Host

Rabbit

Reactivity

Mouse, Rat, Human

Application

WB

Platform ID

BAB871116130

Abcam

Headquarters

Discovery Drive Cambridge Biomedical Campus Cambridge CB2 0AX UK

Contact

Tel: +44 (0)1223 696000
Fax: +44 (0)1223 215 215

Product Specifications
Scientific Background

Specifications

NameAnti-LGR5 antibody [EPR3065Y]
Cat. No.AB75850
HostRabbit
IsotypeIgG
ReactivityMouse, Rat, Human
ApplicationWB
ClonalityMonoclonal
Clone NumberEPR3065Y
Concentration0.114 mg/mL Batch dependent concentration
ImmunogenThe exact immunogen used to generate this antibody is proprietary information.
PurityAffinity purification Protein A
Appearance/FormLiquid
ShippingBlue Ice
FormulationpH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Storage-20°C
Regulatory StatusResearch Use Only

Scientific Background

Target data Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. See full target information LGR5

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